CBD Alleviates Symptoms Of Schizophrenia

The rebirth of cannabinoid-based science strongly suggests that cannabinoids have numerous other applications besides reducing pain. In the paper summarized here, the scientists find that CBD (cannabidiol) provides effective relief from symptoms of schizophrenia. In some strains of marijuana, CBD content is comparable or displaces THC. Historic research found CBD to be the predominant cannabinoid in the Indica strains. Unfortunately, growers bred Indica strains to produce the psychoactive THC instead. Research found that CBD provided a variety of desirable effects for patients, and growers have refocused on developing strains where CBD predominates. Research on CBD’s effects on schizophrenia comes from Professor FM Leweke of the Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg. Leweke found that CBD is as effective at improving psychotic symptoms as the standard antipsychotic amisulpride. Cannabidiol also generated significantly fewer side effects of motor disturbances (so-called extrapyramidal symptoms), weight gain and sexual dysfunction. Leweke’s findings suggest a link between the antipsychotic effects of cannabidiol and CBD’s ability to inhibit anandamide degradation. CBD may enhance anandamide signaling by inhibiting the enzyme that degrades anandamide (fatty acid amide hydrolase-FAAH). The study used dosages of 200 to 600 mg per day. A high yield CBD strain may contain 5% or 50 mg/ gram. Thus, a patient would have to consume 12 grams of CBD-yielding Indica to get the same effect as 600 mg per day. A patient could undertake such a regimen, but it would be costly and probably unpleasant. On the other hand, CBD…

Sex, Hormones, and Cannabis Potency

Have you ever heard that women get cranky and crave chocolate during a specific time of the month? Most people know that the menstrual cycle triggers certain behavior, but until recently science has failed to acknowledge that varying levels of hormones in females altered mood, behavior, and cognitive function (ie. memory, concentration, etc.). Because diseases such as Alzheimer’s, anxiety, depression, and arthritis occur more frequently in females, understanding female specific factors in therapeutics remains important. Estrogen is abundant in the brain and plays an important role in how the brain communicates. Though both men and women have estrogen, its levels only vary in pre-menopausal women as a function of the menstrual cycle (see graph below). Females might not be surprised to hear that they may crave chocolate during certain points in their menstrual cycle, but may not think something like cannabis potency could vary as a result of hormonal fluctuation. However, studies show that the potency of THC on pain relief in female rats increases during times of high estrogen levels. Estrogen appears to play a two-fold effect in cannabis messaging within the brain. First, it increases the conversion of THC to active THC. This means that after THC consumption, more active THC will be produced when estrogen levels are high such as during the pre-ovulatory peak; thus less cannabis may be needed to produce the same effects. Secondly, it changes the availability and excitability of receptors. Since the therapeutic effects of cannabis occur through activation of receptors, the variability…

Terpenes: Effects in Medical Marijuana

The first thing people really notice upon inspecting a new supply of medical marijuana is - the aroma. What gives each plant its particular smell is the complex array of terpenes - the organic chemical makeup of the plant. How they relate with cannabinoids is the subject of much modern research. What is known is that terpenes are volatile, fragrant substances formed in the early steps of making proteins, amino acids, etc. They are not as immediately necessary as, say, water, but they do provide the structure for a plant to survive over time. Hundreds of components have been identified in cannabis varieties; some major terpenes present in all cannabis plants, and their generally recognized effects, are as follows: Alpha-pinene is a basic protective component; its function is improving respiration/circulation, disinfecting and repelling pests. (Think evergreen forest floor, early in the morning). Limonene is a calmative component, recognizeable as a lemony smell. It is a mood brightener and strong pestilent repellant. Alone these terpenes are somewhat aggressive/irritant but in mixtures they offer a strong foundation. Research does demonstrate an "entourage" effect for terpenes, where the final therapeutic impact of the whole plant is more than the sum of its parts. Cannabis also contains linolool, which induces calm, perhaps by modifying response of neurons to L-[H3] glutamate (Phytomedicine, 1999. 6(2), pp 107-113). Finally, myrcene is both sedative and anti-spasmodic (relaxing all muscles); it is also analgesic and anti-inflammatory. Beta caryophyllene is a sesquiterpene, as opposed to the above monoterpenes, and is…

CNN’s Dr. Sanjay Gupta’s Weed Documentaries

The issue of CBD seizure intervention has recently received major visibility by a report by CNN Chief Medical Correspondent, neurologist Sanjay Gupta.  In both Weeds and Weeds 2 (YouTube), he has given substantial airtime evidence to alternate opinions from the general bureaucratic presumption that marijuana is highly addictive with no medical potential. Although there is a major oversimplification stating that the yin/yang CBD and THC are the only potent components, we do learn many things about the history of and current international research into cannabis in the two CNN programs. In the doc we meet Charlotte, who suffered debilitating and increasing seizures that had proven drug-resistant and saw her parents, formerly totally anti-cannabis, search for and find a last best hope - a CBD-rich mj strain eventually named in her honor, "Charlotte's Web."  Colorado just happens to be home to the Stanley brothers, who just happened to have the capability to supply daily medicine from CBD plants, a happy situation for Charlotte. The documentary also covers other topics and issues around the benefits, business and legality of the emerging cannabis industry. It's definitely worth a watch.

Sacramento Cannabis Cup Winners 2012

Cornerstone is proud to have 3 FIRST PLACE WINNERS in the Medicinal Cannabis Cup. Cornerstone's C3 strain has high THC and entourage effects. Cornerstone's Four Cups strain provides relief from anxiety and depression. And, Cornerstone's Blueberry OG is a high CBD medicine with strong anti-inflammatory effects. Cornerstone also earned two HONORABLE MENTIONS for our Cheese (high THC) and CRC Harlequin (high CBD anti-inflammatory) strains.