Cannabis and Autism: Can Cannabis Reverse Advanced Social Impairment?

In the past, we’ve discussed the wonderfully complex relationship between cannabis and various neurological disorders. As more and more research comes to light, it’s become alarmingly clear that the endocannabinoid system that regulates the human body’s response to cannabis is also inextricably involved in healthy brain functioning. Whether they’re keeping the brain’s immune system from attacking healthy cells or simply altering brain wave patterns, cannabinoid receptors are involved in the day to day of neuronal “management”. In the state of California, one of the approved reasons a doctor can prescribe a medical cannabis recommendation is for “social anxiety”. This term is somewhat purposefully vague and seems to cover a lot of conditions. However, the impetus behind the inclusion is real: many cannabis patients specifically consume cannabis to combat anxiety about social situations that can be otherwise absolutely crippling. Something about consuming cannabis gives them the relaxation or edge to feel comfortable enough in social settings to function properly. Of course, it might be easy to chalk this up as an effect of absolutely any social drug; one could say the same about alcohol. However, there is an important differentiation here, being that cannabis, unlike alcohol, is not generally an inhibition lowering substance. Drunk drivers tend to drive too fast. Stoned drivers tend to observe the speed limit or drive too slowly. Regardless, without much legitimate research on the topic, we’ve been curious about this association between cannabis and social functioning. Thankfully, researchers from UC Irvine have released a new study…

Treating Stress & Anxiety Disorders with Cannabis

If you’re a patient suffering from stress or anxiety, there’s good news: researchers are making interesting new in-roads into the biological mechanisms capable of alleviating these conditions.  A recent report published in the medical journal Biology of Mood & Anxiety Disorders sheds light on the effects cannabis use might have on alleviating stress and anxiety by focusing on endogenous cannabinoids (eCBs) found in cannabis and their respective brain receptors. A growing body of evidence has shown that this system plays crucial roles in managing stress, anxiety, and stress-related psychiatric illness. So far, one of the most useful approaches to understanding the eCB system has been to utilize genetically modified mice. In this approach, researchers delete genes that produce cannabinoid receptors, rendering the mice unable to absorb/use cannabinoids. Scientists have found that these mice exhibit a trend of high anxiety, impaired stress coping, and stress-induced psychopathology (gauged by accepted benchmark tests for rodents). While these effects seem to depend on what part of the brain and what specific neurons the receptors are attached to, the overwhelming trend is that mice lacking receptors also perform poorly, which implies that the eCB system is an essential part of stress and anxiety management. Another useful approach has been investigating chemical inhibitors that slow the rate of the enzymes (FAAH and MAGL) that naturally dispose/recycle eCBs. This approach is similar to many commercially available anti-depressants: the pill itself does not contain serotonin (the lack of which has been related to mood disorder), but rather a…

Sacramento Cannabis Cup Winners 2012

Cornerstone is proud to have 3 FIRST PLACE WINNERS in the Medicinal Cannabis Cup. Cornerstone's C3 strain has high THC and entourage effects. Cornerstone's Four Cups strain provides relief from anxiety and depression. And, Cornerstone's Blueberry OG is a high CBD medicine with strong anti-inflammatory effects. Cornerstone also earned two HONORABLE MENTIONS for our Cheese (high THC) and CRC Harlequin (high CBD anti-inflammatory) strains.